Article

The CPEB3 ribozyme modulates hippocampal-dependent memory

2021-01-24

Abstract excerpt

A self-cleaving ribozyme mapping to an intron of the cytoplasmic polyadenylation element binding protein 3 ( CPEB3 ) gene has been suggested to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. The ribozyme’s self-scission half-life matches the time it takes an RNA polymerase to reach the immediate downstream exon, suggesting that the ribozyme-dependent intro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e91aa1f6-6fc8-509f-95f3-be43f4817baf
DOI: 10.1101/2021.01.23.426448

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The CPEB3 ribozyme modulates hippocampal-dependent memoryDOI 10.1101/2021.01.23.426448Read

Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memorySemantic proximity Read

HDV-like self-cleaving ribozymesSemantic proximity Read

The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3.Semantic proximity Read

Large-scale changes to mRNA polyadenylation in temporal lobe epilepsySemantic proximity Read

Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain.Semantic proximity Read

A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.Semantic proximity Read

Neuron type-specific mRNA translation programs provide a gateway for memory consolidationSemantic proximity Read

On the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3Semantic proximity Read

CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged miceSemantic proximity Read

Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover.Semantic proximity Read

Dynamically expressed ELAV is required for learning and memory in beesSemantic proximity Read

Experimental Resurrection of Ancestral Mammalian CPEB3 Ribozymes Reveals Deep Functional Conservation.Semantic proximity Read