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Article

A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.

Science (New York, N.Y.) - 22 Sept 2006

Salehi-Ashtiani Kourosh, Lupták Andrej, Litovchick Alexander, Szostak Jack W

Abstract excerpt

Ribozymes are thought to have played a pivotal role in the early evolution of life, but relatively few have been identified in modern organisms. We performed an in vitro selection aimed at isolating self-cleaving RNAs from the human genome. The selection yielded several ribozymes, one of which is a conserved mammalian sequence that resides in an intron of the CPEB3 gene, which belongs to a family of genes...

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PMID: 16990549
DOI: 10.1126/science.1129308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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