Back to search

Article

Serum Exosomes from a Uniquely Defined Early-Adult Donor Cohort Reprogram Endothelial Transcriptomes Linked to Alzheimer’s Pathogenesis

2025-11-21

Abstract excerpt

Age-related changes in circulating exosomes are implicated in cerebrovascular aging and the pathogenesis of Alzheimer’s disease (AD). Neurovascular dysfunction and blood-brain barrier (BBB) breakdown are recognized as early events in AD, often preceding amyloid-β deposition. Primary human brain micro endothelial cells (HBMECs) from a 38-year-old male were treated with exosomes from young (18–25 years) and old (65–...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e907723f-0ef3-527f-92a0-631c48e062dc
DOI
10.1101/2025.11.20.689131
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Serum Exosomes from a Uniquely Defined Early-Adult Donor Cohort Reprogram Endothelial Transcriptomes Linked to Alzheimer’s PathogenesisDOI 10.1101/2025.11.20.689131
Zonation-dependent single-endothelial cell transcriptomic changes in the aged brainSemantic proximity
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular agingSemantic proximity
Multi-omics integrative approach of senescent endothelial cells and derived extracellular vesicles in a replicative senescence modelSemantic proximity
Transcriptomic Modulation by Exosomes Derived from Human Adipose Stem Cells in Neuronal Cells: Insights from mRNA Sequencing AnalysisSemantic proximity
Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming and increased inflammation in the aging brainSemantic proximity
Application of Multiomics Approach to Investigate the Therapeutic Potentials of Stem Cell-derived Extracellular Vesicle Subpopulations for Alzheimer’s DiseaseSemantic proximity
Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s diseaseSemantic proximity
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brainSemantic proximity
Brain endothelial cells are exquisite sensors of age-related circulatory cuesSemantic proximity
Multimodal analysis identifies pericyte-centered signaling programs altered by sex and brain region in Alzheimer’s DiseaseSemantic proximity
Exosomes Released from Senescent Cells and Circulatory Exosomes Isolated from Human Plasma Reveal Aging-associated Proteomic and Lipid SignaturesSemantic proximity
A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brainSemantic proximity
Select a neighboring publication to make it the new centre.