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Article

A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition.

Proteins - 1 Apr 2016

Murray Brian, Sorci Mirco, Rosenthal Joseph, Lippens Jennifer, Isaacson David, Das Payel, Fabris Daniele, Li Shaomin, Belfort Georges

Abstract excerpt

The histopathological hallmark of Alzheimer's disease (AD) is the aggregation and accumulation of the amyloid beta peptide (Aβ) into misfolded oligomers and fibrils. Here we examine the biophysical properties of a protective Aβ variant against AD, A2T, and a causative mutation, A2T, along with the wild type (WT) peptide. The main finding here is that the A2V native monomer is more stable than both A2T and WT, and...

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PMID: 26799157
DOI: 10.1002/prot.24995

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