Article

Biochemical characterization and essentiality of <i>Plasmodium</i> fumarate hydratase

2017-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Plasmodium falciparum (Pf), the causative agent of malaria has an iron-sulfur cluster-containing class I fumarate hydratase (FH) that catalyzes the interconversion of fumarate to malate, a well-known reaction in the tricarboxylic acid cycle. In humans, the same reaction is catalyzed by class II FH that has no sequence or structural homology with the class I enzyme. Fumarate, generated in large q...

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Literature Corpus work: e8e0ecb0-305c-5800-aa8c-35a8283707ac
DOI: 10.1101/158956

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