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Host porphobilinogen deaminase deficiency confers malaria resistance in <i>Plasmodium chabaudi</i> but not in <i>Plasmodium berghei</i> or <i>Plasmodium falciparum</i> during intraerythrocytic growth

2019-03-27

Abstract excerpt

<h4>ABSTRACT</h4> An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be useful for developing new treatment strategies. A mouse ENU-induced mutagenesis screen for novel malaria resistance-conferring mutations identified...

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Literature Corpus work
91597837-07c1-54c3-bc03-cf26bd524c28
DOI
10.1101/589242
Open publication

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