Article

Accelerated metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia

2025-05-11

Abstract excerpt

<h4>Background</h4> Identifying individuals at risk of dementia is essential for prevention and targeted disease-modifying strategies. We investigated whether metabolomic ageing in mid-life is associated with incident dementia and dementia age of onset. We also explored joint associations and interactions with genetic risk, including APOE genotype and dementia polygenic scores. <h4>Methods</h4> The UK Biobank...

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Literature Corpus work: e8c176c0-db90-5071-a7fc-140dbc72e35f
DOI: 10.1101/2025.05.09.25327305

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