Article

Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells

2019-10-04

Abstract excerpt

<h4>ABSTRACT</h4> The majority of gastrointestinal stromal tumors (GISTs) are driven by oncogenic KIT signaling and can therefore be effectively treated with the tyrosine kinase inhibitor (TKI) imatinib mesylate. However, most GISTs develop imatinib resistance through secondary KIT mutations. The type of resistance mutation determines sensitivity to approved second-/third-line TKIs but shows high inter- and intr...

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Literature Corpus work: 19196a68-abd8-52cf-b606-fea8886094f2
DOI: 10.1101/791426

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