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Article

USP7 inhibition perturbs proteostasis and tumorigenesis in triple negative breast cancer

2025-02-03

Abstract excerpt

<h4>ABSTRACT</h4> The deubiquitinase USP7 is a critical regulator of tumorigenesis, known for stabilizing the MDM2-p53 pathway. Emerging evidence highlights USP7’s p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers frequently inactivate p53 and this disease subtype remains difficult to treat and in need of new therapeutic options. Our study reveals that USP7 is upregulated in...

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Literature Corpus work
7245be97-eedb-5503-9f24-d1449848d9f0
DOI
10.1101/2025.01.28.635372
Open publication

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USP7 inhibition perturbs proteostasis and tumorigenesis in triple negative breast cancerDOI 10.1101/2025.01.28.635372
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