Article

Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations

2025-07-04

Abstract excerpt

The extent to which genetic effects vary across ancestries remains a central question in human genetics, with direct implications for improving polygenic prediction. Recent studies have found that average causal effects are similar across ancestries, but empirical evidence and theoretical considerations suggest that interactions may still contribute to poor portability of polygenic scores. Here, we leverage the an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8adcdfa-2b53-5f83-bad2-bfd4e9682b86
DOI: 10.1101/2025.06.30.662316

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populationsDOI 10.1101/2025.06.30.662316Read

Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations.Semantic proximity Read

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals.Semantic proximity Read

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity Read

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity Read

Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.Semantic proximity Read

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.Semantic proximity Read

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a ModelSemantic proximity Read

Admixture-informed polygenic risk reporting using the ePRS framework.Semantic proximity Read

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statisticsSemantic proximity Read

Leveraging local ancestry to detect gene-gene interactions in genome-wide data.Semantic proximity Read

Impact of cross-ancestry genetic architecture on GWASs in admixed populations.Semantic proximity Read

Testing for differences in polygenic scores in the presence of confounding.Semantic proximity Read