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Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence

5 Mar 2020

Abstract excerpt

Chromosomal instability (CIN) refers to the rate at which cells are unable to properly segregate whole chromosomes, leading to aneuploidy. Besides its prevalence in cancer cells and postulated implications in promoting tumorigenesis, studies in aneuploidy-prone mouse models uncovered an unanticipated link between CIN and aging. Using young to old-aged human dermal fibroblasts, we observed a dysfunction of the...

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PMID: 32134180
DOI: 10.15252/embr.201949248

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