Article

WEE1 kinase inhibition triggers severe chromosome pulverization in aneuploid cells

2023-09-19

Abstract excerpt

Aneuploidy, a hallmark of cancer, is a prominent feature associated with poor prognosis in breast cancer. Here, we screened a panel of cell cycle kinase inhibitors to identify novel targets for highly aneuploid breast cancers. We show that increasing aneuploidy in breast cancer cells sensitizes to the inhibition of WEE1 kinase. Upon exposure to WEE1 inhibitor, aneuploid cells exhibit aberrant mitosis characterized...

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Literature Corpus work: a053d973-6438-5848-b3ee-5754c230c2e9
DOI: 10.1101/2023.09.19.558475

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