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BioPhi: A platform for antibody design, humanization and humanness evaluation based on natural antibody repertoires and deep learning

2021-08-08

Abstract excerpt

Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains the primary route for therapeutic antibody development. Traditionally, humanization is manual, laborious, and requires expert knowledge. Although automation efforts are advancing, existing methods are either demonstrated on a small scale or are entirely proprietary. To predict the immunogenicity ri...

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Literature Corpus work
e887ed45-15b2-5518-b2be-022874e3c124
DOI
10.1101/2021.08.08.455394
Open publication

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BioPhi: A platform for antibody design, humanization and humanness evaluation based on natural antibody repertoires and deep learningDOI 10.1101/2021.08.08.455394
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