Article

Humatch - fast, gene-specific joint humanisation of antibody heavy and light chains

2024-09-19

Abstract excerpt

1 Antibodies are a popular and powerful class of therapeutic due to their ability to exhibit high affinity and specificity to target proteins. However, the majority of antibody therapeutics are not genetically human, with initial therapeutic designs typically obtained from animal models. Humanisation of these precursors is essential to reduce immunogenic risks when administered to humans. Here, we present Humatch,...

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Literature Corpus work: 69aae840-8177-5806-98e3-80053856ab5a
DOI: 10.1101/2024.09.16.613210

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