Article

Humanization of antibodies using a machine learning approach on large-scale repertoire data

2021-01-08

Abstract excerpt

Monoclonal antibody therapeutics are often produced from non-human sources (typically murine), and can therefore generate immunogenic responses in humans. Humanization procedures aim to produce antibody therapeutics that do not elicit an immune response and are safe for human use, without impacting efficacy. Humanization is normally carried out in a largely trial-and-error experimental process. We have built machi...

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Literature Corpus work: cda98809-0ac1-58c7-b580-86391accf1fb
DOI: 10.1101/2021.01.08.425894

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