Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation.

doi:10.1016/j.stemcr.2019.11.003

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Article

Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation.

Stem cell reports - 10 Dec 2019

Hildebrandt Matthew R, Reuter Miriam S, Wei Wei, Tayebi Naeimeh, Liu Jiajie, Sharmin Sazia, Mulder Jaap, Lesperance L Stephen, Brauer Patrick M, Mok Rebecca S F, Kinnear Caroline, Piekna Alina, Romm Asli, Howe Jennifer, Pasceri Peter, Meng Guoliang, Rozycki Matthew, Rodrigues Deivid C, Martinez Elisa C, Szego Michael J, Zúñiga-Pflücker Juan C, Anderson Michele K, Prescott Steven A, Rosenblum Norman D, Kamath Binita M, Mital Seema, Scherer Stephen W, Ellis James

Abstract excerpt

Induced pluripotent stem cells (iPSC) derived from healthy individuals are important controls for disease-modeling studies. Here we apply precision health to create a high-quality resource of control iPSCs. Footprint-free lines were reprogrammed from four volunteers of the Personal Genome Project Canada (PGPC). Multilineage-directed differentiation efficiently produced functional cortical neurons, cardiomyocytes...

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Identifiers

PMID: 31813827
DOI: 10.1016/j.stemcr.2019.11.003
PMCID: PMC6915802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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