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Article

A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism.

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015

Li Gang, Nguyen Christopher C, Ryckman Brent J, Britt William J, Kamil Jeremy P

Abstract excerpt

Viral glycoproteins mediate entry of enveloped viruses into cells and thus play crucial roles in infection. In herpesviruses, a complex of two viral glycoproteins, gH and gL (gH/gL), regulates membrane fusion events and influences virion cell tropism. Human cytomegalovirus (HCMV) gH/gL can be incorporated into two different protein complexes: a glycoprotein O (gO)-containing complex known as gH/gL/gO, and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25831500
DOI: 10.1073/pnas.1419875112
PMCID: PMC4394275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism.PMID 25831500Read ↗

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Expression Levels of Glycoprotein O (gO) Vary between Strains of Human Cytomegalovirus, Influencing the Assembly of gH/gL Complexes and Virion InfectivitySemantic proximity Read ↗

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