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Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions

15 Apr 2016

Abstract excerpt

Human cytomegalovirus (HCMV) is a ubiquitous virus that is a major pathogen in newborns and immunocompromised or immunosuppressed patients. HCMV infects a wide variety of cell types using distinct entry pathways that involve different forms of the gH/gL glycoprotein: gH/gL/gO and gH/gL/UL128-131 as well as the viral fusion glycoprotein, gB. However, the minimal or core fusion machinery (sufficient for cell-cell...

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PMID: 27082872
DOI: 10.1371/journal.ppat.1005564

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Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in VirionsPMID 27082872Read ↗

Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism.Semantic proximity Read ↗

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodiesSemantic proximity Read ↗

Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131Semantic proximity Read ↗

Characterization of the Human Cytomegalovirus gH/gL/UL128-131 Complex That Mediates Entry into Epithelial and Endothelial CellsSemantic proximity Read ↗

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodiesSemantic proximity Read ↗

Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131.Semantic proximity Read ↗

Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope.Semantic proximity Read ↗

Human Cytomegalovirus Glycoproteins gB and gH/gL Mediate Epithelial Cell-Cell Fusion When Expressed either in <i>cis</i> or in <i>trans</i>Semantic proximity Read ↗

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes.Semantic proximity Read ↗

Human Cytomegalovirus Glycoprotein gO Complexes with gH/gL, Promoting Interference with Viral Entry into Human Fibroblasts but Not Entry into Epithelial CellsSemantic proximity Read ↗

A dual role in virion attachment and entry makes the human cytomegalovirus gHgLgO trimer the central player in virion infectivitySemantic proximity Read ↗

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.Semantic proximity Read ↗

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