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Article

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes.

Proceedings of the National Academy of Sciences of the United States of America - 10 Feb 2015

Ciferri Claudio, Chandramouli Sumana, Donnarumma Danilo, Nikitin Pavel A, Cianfrocco Michael A, Gerrein Rachel, Feire Adam L, Barnett Susan W, Lilja Anders E, Rappuoli Rino, Norais Nathalie, Settembre Ethan C, Carfi Andrea

Abstract excerpt

Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and the leading viral cause of birth defects after congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are key targets of the human humoral response against HCMV and are required for HCMV entry into fibroblasts and endothelial/epithelial cells, respectively. We expressed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25624487
DOI: 10.1073/pnas.1424818112
PMCID: PMC4330774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes.PMID 25624487Read ↗

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