Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site.

doi:10.1128/JVI.01255-17

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Article

Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site.

Journal of virology - 1 Dec 2017

Möhl Britta S, Chen Jia, Park Seo Jin, Jardetzky Theodore S, Longnecker Richard

Abstract excerpt

Epstein-Barr virus (EBV) entry into epithelial cells is mediated by the conserved core fusion machinery, composed of the fusogen gB and the receptor-binding complex gH/gL. The heterodimeric gH/gL complex binds to the EBV epithelial cell receptor or gp42, which binds to the B-cell receptor, triggering gB-mediated fusion of the virion envelope with cellular membranes. Our previous study found that the gL...

Topics

Animals
CHO Cells
Cricetulus
Epithelial Cells
Giant Cells
Glycosylation
Green Fluorescent Proteins
Herpesvirus 4, Human
Kinetics
Membrane Fusion
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Chaperones

Mutation

Protein Binding

Viral Envelope Proteins

Viral Proteins

Virus Internalization

Source

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Identifiers

PMID: 28956769
DOI: 10.1128/JVI.01255-17
PMCID: PMC5686762

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