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Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies

9 Apr 2025

Abstract excerpt

Herpesviruses require membrane fusion for entry and spread, a process facilitated by the fusion glycoprotein B (gB) and the regulatory factor gH/gL. The human cytomegalovirus (HCMV) gH/gL can be modified by the accessory protein gO, or the set of proteins UL128, UL130, and UL131. While the binding of the gH/gL/gO and gH/gL/UL128-131 complexes to cellular receptors, including PDGFRα and NRP2, has been...

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PMID: 40202318
DOI: 10.1128/jvi.00035-25

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Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodiesPMID 40202318Read ↗

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodiesSemantic proximity Read ↗

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.Semantic proximity Read ↗

Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131Semantic proximity Read ↗

Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131.Semantic proximity Read ↗

Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism.Semantic proximity Read ↗

Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in VirionsSemantic proximity Read ↗

A dual role in virion attachment and entry makes the human cytomegalovirus gHgLgO trimer the central player in virion infectivitySemantic proximity Read ↗

The N Terminus of Human Cytomegalovirus Glycoprotein O Is Important for Binding to the Cellular Receptor PDGFRαSemantic proximity Read ↗

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Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics.Semantic proximity Read ↗

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