Article
In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.
Molecular therapy : the journal of the American Society of Gene Therapy - 3 Jan 2018
Ojala David S, Sun Sabrina, Santiago-Ortiz Jorge L, Shapiro Mikhail G, Romero Philip A, Schaffer David V
Abstract excerpt
Directed evolution continues to expand the capabilities of complex biomolecules for a range of applications, such as adeno-associated virus vectors for gene therapy; however, advances in library design and selection strategies are key to develop variants that overcome barriers to clinical translation. To address this need, we applied structure-guided SCHEMA recombination of the multimeric adeno-associated virus...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.