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Article

LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner <i>via</i> its armadillo domain

25 Sept 2019

Abstract excerpt

LRRK2 is a multi-domain Ser/Thr kinase that is associated with inherited and sporadic cases of Parkinson’s disease. Many mutations linked to disease are associated within a central ROC-COR regulatory region and the subsequent kinase domain, leading to enhanced catalytic activity. The N-terminus of human LRRK2 consists of armadillo repeat motifs (ARMs) followed by ankyrin repeats (ANKs). Recently, Rab GTPases have...

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PMID: 31552791
DOI: 10.1080/21541248.2019.1666623

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