Unveiling Frailty: Comprehensive and Sex-Specific Characterization in Prematurely Aging PolgA Mice

Abstract excerpt

Frailty, a geriatric syndrome, is assessed using the frailty phenotype (FP) and frailty index (FI). While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgA D257A/D257A (PolgA) has not been completely explored. We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decr...

Topics

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• Biomarkers
• Bone Density
• Disease Models, Animal
• Frailty
• Geriatric Assessment
• Hand Strength
• Mice
• Mice, Inbred C57BL

Identifiers and source

Literature Corpus work

e821851c-b6b6-5940-a0f3-06ca755fd0d1

DOI

10.1101/2024.02.15.580562