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Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications.

Experimental gerontology - 1 May 2022

Mach John, Allore Heather, Gnjidic Danijela, Gemikonakli Gizem, Kane Alice E, Howlett Susan E, de Cabo Rafael, Le Couteur David, Hilmer Sarah N

Abstract excerpt

Use of different objective frailty assessment tools may improve understanding of the biology of frailty and allow evaluation of effects of interventions on frailty. Polypharmacy is associated with increased risk of frailty in epidemiologic studies, regardless of frailty definition, but the pathophysiology of the association is not well understood. This study aims to (1) assess and compare the prevalence of...

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PMID: 35032570
DOI: 10.1016/j.exger.2022.111700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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