Article

Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotype

2021-06-22

Abstract excerpt

Recent preclinical and clinical data suggests enhanced metastatic fitness of hybrid epithelial/ mesenchymal (E/M) phenotypes, but mechanistic details regarding their survival strategies during metastasis remain unclear. Here, we investigate immune-evasive strategies of hybrid E/M states. We construct and simulate the dynamics of a minimalistic regulatory network encompassing the known associations among regulators...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e81ce81c-5829-5b1d-a926-ae7ca8c0aef8
DOI: 10.1101/2021.06.21.449285

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotypeDOI 10.1101/2021.06.21.449285Read

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype.Semantic proximity Read

Hybrid E/M phenotype(s) and stemness: a mechanistic connection embedded in network topologySemantic proximity Read

Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network TopologySemantic proximity Read

NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial/mesenchymal phenotypeSemantic proximity Read

Biophysical and Biochemical Attributes of Hybrid Epithelial/Mesenchymal PhenotypesSemantic proximity Read

Network topology metrics explaining enrichment of hybrid epithelial/mesenchymal phenotypes in metastasis.Semantic proximity Read

Emerging Concepts of Hybrid Epithelial-to-Mesenchymal Transition in Cancer ProgressionSemantic proximity Read

Stability and mean residence times for hybrid epithelial/mesenchymal phenotype.Semantic proximity Read

Biophysical and biochemical attributes of hybrid epithelial/mesenchymal phenotypes.Semantic proximity Read

Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical ImplicationsSemantic proximity Read

Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancerSemantic proximity Read

Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?Semantic proximity Read