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Article

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype.

Frontiers in immunology - 1 Jan 2021

Sahoo Sarthak, Nayak Sonali Priyadarshini, Hari Kishore, Purkait Prithu, Mandal Susmita, Kishore Akash, Levine Herbert, Jolly Mohit Kumar

Abstract excerpt

Recent preclinical and clinical data suggests enhanced metastatic fitness of hybrid epithelial/mesenchymal (E/M) phenotypes, but mechanistic details regarding their survival strategies during metastasis remain unclear. Here, we investigate immune-evasive strategies of hybrid E/M states. We construct and simulate the dynamics of a minimalistic regulatory network encompassing the known associations among regulators...

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Identifiers

PMID: 34975907
DOI: 10.3389/fimmu.2021.797261
PMCID: PMC8714906

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