Article

Hybrid E/M phenotype(s) and stemness: a mechanistic connection embedded in network topology

2020-10-18

Abstract excerpt

Metastasis remains an unsolved clinical challenge. Two crucial features of metastasizing cancer cells are a) their ability to dynamically move along the epithelial-hybrid-mesenchymal spectrum and b) their tumor-initiation potential or stemness. With increasing functional characterization of hybrid epithelial/mesenchymal (E/M) phenotypes along the spectrum, recent in vitro and in vivo studies have suggested an in...

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Literature Corpus work: 39ba9858-64ed-51f6-a8ad-d9ba56034535
DOI: 10.1101/2020.10.18.341271

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