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Article

Network topology metrics explaining enrichment of hybrid epithelial/mesenchymal phenotypes in metastasis.

PLoS computational biology - 1 Nov 2022

Rashid Mubasher, Hari Kishore, Thampi John, Santhosh Nived Krishnan, Jolly Mohit Kumar

Abstract excerpt

Epithelial to Mesenchymal Transition (EMT) and its reverse-Mesenchymal to Epithelial Transition (MET) are hallmarks of metastasis. Cancer cells use this reversible cellular programming to switch among Epithelial (E), Mesenchymal (M), and hybrid Epithelial/Mesenchymal (hybrid E/M) state(s) and seed tumors at distant sites. Hybrid E/M cells are often more aggressive and metastatic than the "pure" E and M cells....

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Source

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Identifiers

PMID: 36346808
DOI: 10.1371/journal.pcbi.1010687
PMCID: PMC9674141

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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