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Article

A multilevel formalism to model the hybrid E/M phenotypes in epithelial-mesenchymal plasticity.

Biophysical journal - 15 Sept 2026

Hari Kishore, Tripathi Shubham, Anand Vaibhav, Jolly Mohit Kumar, Levine Herbert

Abstract excerpt

Epithelial-mesenchymal plasticity is a cell-fate switching program that enables cells to adopt a spectrum of phenotypes ranging from epithelial (E) to mesenchymal (M), including intermediate hybrid E/M states. Hybrid E/M phenotypes are conducive to cancer metastasis, as they are associated with metastatic initiation, cancer stemness, drug resistance, and collective migration. Boolean models of the gene regulatory...

Read the complete abstract on PubMed

Topics

Phenotype
Epithelial-Mesenchymal Transition
Models, Biological
Gene Regulatory Networks
Epithelial Cells
Animals

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Identifiers

PMID: 41272973
DOI: 10.1016/j.bpj.2025.11.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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