Article
Stability and mean residence times for hybrid epithelial/mesenchymal phenotype.
Physical biology - 29 Jan 2019
Biswas Kuheli, Jolly Mohit Kumar, Ghosh Anandamohan
Abstract excerpt
Cancer metastasis and drug resistance remain unsolved clinical challenges. A phenotypic transition that is often implicated in both these processes is epithelial-mesenchymal transition (EMT) during which epithelial cells weaken their cell-cell adhesion and gain traits of migration and invasion, typical of mesenchymal cells. However, recent studies indicate that apart from these two states, cells can also exist in...
Topics
- Computational Biology
- Epithelial Cells
- Epithelial-Mesenchymal Transition
- Gene Expression
- Gene Regulatory Networks
- Mesenchymal Stem Cells
- Models, Genetic
- Phenotype
- Stochastic Processes