Article

The AP-1 factors <i>FOSL1</i> and <i>FOSL2</i> co-regulate human Th17 responses

2021-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Th17 cells protect mucosal barriers, but their aberrant activity can cause autoimmunity. Molecular networks dictating human Th17 function are largely unexplored, and this hinders disease-studies. Here, we investigated the roles of the AP-1 factors, FOSL1 and FOSL2, in inducing human Th17 responses. Transient knockdown and over-expression strategies found the two proteins to inhibit Th17-cell i...

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Literature Corpus work: 305e9fb8-5caa-5f45-94ac-63c8cd6939e9
DOI: 10.1101/2021.04.26.441472

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