Article

A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology

2022-12-13

Abstract excerpt

Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics. Here, we present an in vitro model of OA pain, where dorsal root ganglion (DRG) sensory neurons were sensitized by a defined mixture of disease-relevant inflammatory mediators, here called Sensitizing PA...

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Literature Corpus work: e7f17173-168b-5bad-822c-c8ece16256f3
DOI: 10.1101/2022.12.12.520139

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