Article

Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets

2025-09-21

Abstract excerpt

The richness of our somatosensory experience is reflected in the functional diversity of somatic sensory neurons. Single-cell sequencing (scRNA) of sensory neurons has revealed a molecular basis for such diversity 1–3 . However, sensory neuron diversity has yet to be captured at the level of the proteome. Here, we combined electrophysiology with deep visual proteomics (DVP) 4 to quantify over 6,000 proteins from...

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Literature Corpus work: 2cf1d687-bedc-5b3f-8dfc-dab6a8cc4dd0
DOI: 10.1101/2025.09.20.677124

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