N-terminal proteoforms may engage in different protein complexes

Abstract excerpt

Alternative translation initiation and alternative splicing may give rise to N-terminal proteoforms, proteins that differ at their N-terminus compared to their canonical counterparts. Such proteoforms can have altered localizations, stabilities and functions. While proteoforms generated from splice variants can be engaged in different protein complexes, it remained to be studied to what extent this applies to N-te...

Topics

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• Advanced biosensing and bioanalysis techniques
• Alternative Splicing
• Databases, Protein
• Gene Ontology
• Peptidase Inhibition and Analysis
• Protein Isoforms
• Protein Processing, Post-Translational
• RNA and protein synthesis mechanisms

Identifiers and source

Literature Corpus work

0a40a233-ecb0-591d-a440-56baec10e52b

DOI

10.1101/2023.01.17.524352