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A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies

14 Jul 2021

Abstract excerpt

Intraneuronal accumulation of hyperphosphorylated tau is a hallmark pathology shown in over twenty neurodegenerative disorders, collectively termed as tauopathies, including the most common Alzheimer's disease (AD). Therefore, selectively removing or reducing hyperphosphorylated tau is promising for therapies of AD and other tauopathies. Here, we designed and synthesized a novel DEPhosphorylation TArgeting...

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PMID: 34262014
DOI: 10.1038/s41392-021-00669-2

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