Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protective role of chaperone-mediated autophagy against atherosclerosis

1 Apr 2022

Abstract excerpt

Chaperone-mediated autophagy (CMA) contributes to regulation of energy homeostasis by timely degradation of enzymes involved in glucose and lipid metabolism. Here, we report reduced CMA activity in vascular smooth muscle cells and macrophages in murine and human arteries in response to atherosclerotic challenges. We show that in vivo genetic blockage of CMA worsens atherosclerotic pathology through both systemic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Calpain Protease Function and Regulation
Share to Endoplasmic Reticulum Stress and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35363568
DOI: 10.1073/pnas.2121133119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protective role of chaperone-mediated autophagy against atherosclerosisPMID 35363568Read ↗

Elucidating the crosstalk between endothelial-to-mesenchymal transition (EndoMT) and endothelial autophagy in the pathogenesis of atherosclerosis.Semantic proximity Read ↗

Autophagy in Cardiovascular AgingSemantic proximity Read ↗

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.Semantic proximity Read ↗

Implications of autophagy for vascular smooth muscle cell function and plasticitySemantic proximity Read ↗

Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.Semantic proximity Read ↗

Comprehensive view of macrophage autophagy and its application in cardiovascular diseasesSemantic proximity Read ↗

Defective Autophagy in Atherosclerosis: To Die or to Senesce?Semantic proximity Read ↗

Autophagy in cardiovascular biologySemantic proximity Read ↗

Macrophage Autophagy in Atherosclerosis: A Central Regulator of Lipid Metabolism, Inflammation, and Plaque Stability as a Novel Therapeutic Target–A Systematic ReviewSemantic proximity Read ↗

Defective autophagy in vascular smooth muscle cells enhances atherosclerotic plaque instabilitySemantic proximity Read ↗

Chaperone-mediated autophagy regulates adipocyte differentiationSemantic proximity Read ↗

Autophagy and Mitophagy in Cardiovascular DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.