Article

Cryptotanshinone Targets HYOU1 to Rewire ER-Mitochondria Communication and Enhance Autophagy in Atherosclerosis

2025-03-28

Abstract excerpt

<title>Abstract</title> <p>Atherosclerosis is driven by chronic lipid accumulation, oxidative stress, and impaired autophagy, yet effective therapies targeting these pathways remain elusive. Oxidized low-density lipoprotein (oxLDL), a major contributor to atherosclerosis, disrupts cellular homeostasis by promoting the formation of mitochondria-associated ER membrane (MAM), which regulate essential processes such...

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Literature Corpus work: 8867df1c-4a7d-5f13-9198-54d92c08ef7e
DOI: 10.21203/rs.3.rs-6301868/v1

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