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Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings

5 Apr 2018

Abstract excerpt

Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are highly specialized subcellular compartments that are shaped by ER subdomains juxtaposed to mitochondria but are biochemically distinct from pure ER and pure mitochondria. MAMs are enriched in enzymes involved in lipid synthesis and transport, channels for calcium transfer, and proteins with oncogenic/oncosuppressive functions that modulate...

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PMID: 29626751
DOI: 10.1016/j.neo.2018.03.005

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