Article

Loss of MYSM1 deubiquitinase catalytic activity protects against MYC-driven B cell lymphoma via tumor intrinsic effects and indirect modulation of antitumor immunity

2026-01-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> MYC is an oncogenic transcription factor that is over-expressed, amplified, or otherwise dysregulated in over 50% of all cancers. This includes over 10% of diffuse large B-cell lymphomas (DLBCL), where MYC translocations are associated with a poor therapy response and inferior prognosis for the patients. However, because MYC lacks ligand-binding or catalytic domains, it is...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7aa734a-27d4-5b88-9e34-930d2070e794
DOI: 10.64898/2026.01.19.700060

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of MYSM1 deubiquitinase catalytic activity protects against MYC-driven B cell lymphoma via tumor intrinsic effects and indirect modulation of antitumor immunityDOI 10.64898/2026.01.19.700060Read

Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.Semantic proximity Read

A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.Semantic proximity Read

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphomaSemantic proximity Read

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.Semantic proximity Read

MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical managementSemantic proximity Read

Targeting CAR-T cell senescence through Mysm1-SSBP1 axis improves persistence and therapeutic efficacySemantic proximity Read

An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation.Semantic proximity Read

Advances in the understanding of MYC‐induced lymphomagenesisSemantic proximity Read

c-MYC–miRNA circuitrySemantic proximity Read

The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 proteinSemantic proximity Read

MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and AgingSemantic proximity Read

The OTUD6B‐LIN28B‐MYC axis determines the proliferative state in multiple myelomaSemantic proximity Read