An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation.

doi:10.1016/j.jaci.2015.06.008

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Article

An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation.

The Journal of allergy and clinical immunology - 1 Dec 2015

Le Guen Tangui, Touzot Fabien, André-Schmutz Isabelle, Lagresle-Peyrou Chantal, France Benoit, Kermasson Laetitia, Lambert Nathalie, Picard Capucine, Nitschke Patrick, Carpentier Wassila, Bole-Feysot Christine, Lim Annick, Cavazzana Marina, Callebaut Isabelle, Soulier Jean, Jabado Nada, Fischer Alain, de Villartay Jean-Pierre, Revy Patrick

Abstract excerpt

BACKGROUND: Myb-Like, SWIRM, and MPN domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiquitinated form of histone 2A (H2A), a chromatin marker associated with gene transcription silencing. Likewise, it has been reported that murine Mysm1 participates in transcription derepression of genes, among which are transcription factors involved in hematopoietic stem cell homeostasis,...

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Identifiers

PMID: 26220525
DOI: 10.1016/j.jaci.2015.06.008

Genes

MYSM1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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