Article

Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifier

2021-10-01

Abstract excerpt

<title>Abstract</title> <p>Outer hair cell electromotility, driven by prestin, is essential for mammalian cochlear amplification. Here, we report the cryo-EM structures of thermostabilized human prestin (hPres<sup>TS</sup>), complexed with chloride, sulfate, or salicylate at 3.52–3.61 Å resolutions, revealing a crossed dimeric arrangement. The central positively-charged cavity allows flexible binding of various a...

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Literature Corpus work: e79ab3b1-614a-5a5f-ade4-783b91586b1f
DOI: 10.21203/rs.3.rs-927386/v1

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