Article
Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein.
Science (New York, N.Y.) - 22 Jun 2001
Oliver D, He D Z, Klöcker N, Ludwig J, Schulte U, Waldegger S, Ruppersberg J P, Dallos P, Fakler B
Abstract excerpt
Outer hair cells (OHCs) of the mammalian cochlea actively change their cell length in response to changes in membrane potential. This electromotility, thought to be the basis of cochlear amplification, is mediated by a voltage-sensitive motor molecule recently identified as the membrane protein prestin. Here, we show that voltage sensitivity is conferred to prestin by the intracellular anions chloride and...
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