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Article

Combinatorial cysteine mutagenesis reveals a critical intramonomer role for cysteines in prestin voltage sensing.

Biophysical journal - 7 Jul 2010

Bai Jun-Ping, Surguchev Alexei, Bian Shumin, Song Lei, Santos-Sacchi Joseph, Navaratnam Dhasakumar

Abstract excerpt

Prestin is a member of the SLC26 family of anion transporters and is responsible for electromotility in outer hair cells, the basis of cochlear amplification in mammals. It is an anion transporting transmembrane protein, possessing nine cysteine residues, which generates voltage-dependent charge...

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Identifiers

PMID: 20655836
DOI: 10.1016/j.bpj.2010.03.066
PMCID: PMC2895379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20655836-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Combinatorial cysteine mutagenesis reveals a critical intramonomer role for cysteines in prestin voltage sensing.PMID 20655836Read ↗

Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin.Semantic proximity Read ↗

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N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Current carried by the Slc26 family member prestin does not flow through the transporter pathway.Semantic proximity Read ↗

Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifierSemantic proximity Read ↗

Cysteine Modification: Probing Channel Structure, Function and Conformational Change.Semantic proximity Read ↗

Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.Semantic proximity Read ↗

A genetically-encoded YFP sensor with enhanced chloride sensitivity, photostability and reduced ph interference demonstrates augmented transmembrane chloride movement by gerbil prestin (SLC26a5).Semantic proximity Read ↗

Restoration of proper trafficking to the cell surface for membrane proteins harboring cysteine mutations.Semantic proximity Read ↗

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplificationSemantic proximity Read ↗

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