Article
The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits.
The Journal of biological chemistry - 25 Jan 2013
Homma Kazuaki, Duan Chongwen, Zheng Jing, Cheatham Mary Ann, Dallos Peter
Abstract excerpt
Outer hair cells (OHCs) are a mammalian innovation for mechanically amplifying sound energy to overcome the viscous damping of the cochlear partition. Although the voltage-dependent OHC membrane motor, prestin, has been demonstrated to be essential for mammalian cochlear amplification, the molecular mechanism by which prestin converts electrical energy into mechanical displacement/force remains elusive....
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