Article
Current carried by the Slc26 family member prestin does not flow through the transporter pathway.
Scientific reports - 19 Apr 2017
Bai Jun-Ping, Moeini-Naghani Iman, Zhong Sheng, Li Fang-Yong, Bian Shumin, Sigworth Fred J, Santos-Sacchi Joseph, Navaratnam Dhasakumar
Abstract excerpt
Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral membrane, GmetL. We determine that prestin itself possesses a stretch-sensitive, non-selective...
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