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Article

Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.

Nature - 19 Sept 2002

Liberman M Charles, Gao Jiangang, He David Z Z, Wu Xudong, Jia Shuping, Zuo Jian

Abstract excerpt

Hearing sensitivity in mammals is enhanced by more than 40 dB (that is, 100-fold) by mechanical amplification thought to be generated by one class of cochlear sensory cells, the outer hair cells. In addition to the mechano-electrical transduction required for auditory sensation, mammalian outer hair cells also perform electromechanical transduction, whereby transmembrane voltage drives cellular length changes at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12239568
DOI: 10.1038/nature01059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.PMID 12239568Read ↗

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplificationSemantic proximity Read ↗

The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits.Semantic proximity Read ↗

Normal hearing sensitivity at low-to-middle frequencies with 34% prestin-charge density.Semantic proximity Read ↗

N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Activity-dependent regulation of prestin expression in mouse outer hair cells.Semantic proximity Read ↗

Biophysics of the cochlea - biomechanics and ion channelopathies.Semantic proximity Read ↗

Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier.Semantic proximity Read ↗

Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation.Semantic proximity Read ↗

Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifierSemantic proximity Read ↗

A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification.Semantic proximity Read ↗

Interaction of prestin (SLC26A5) with monovalent intracellular anions.Semantic proximity Read ↗

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