Article

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplification

2024-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Prestin’s voltage-driven motor activity confers sound-elicited somatic electromotility in auditory outer hair cells (OHCs) and is essential for the exquisite sensitivity and frequency selectivity of mammalian hearing. Lack of prestin results in hearing threshold shifts across frequency, supporting the causal association of variants in the prestin-coding gene, SLC26A5 , with human hearing loss,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f79698d-3f18-53c6-a83c-fd731e757e27
DOI: 10.1101/2024.05.22.595389

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplificationDOI 10.1101/2024.05.22.595389Read

The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits.Semantic proximity Read

Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.Semantic proximity Read

Normal hearing sensitivity at low-to-middle frequencies with 34% prestin-charge density.Semantic proximity Read

The R130S mutation significantly affects the function of prestin, the outer hair cell motor protein.Semantic proximity Read

Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier.Semantic proximity Read

The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing loss.Semantic proximity Read

The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing lossSemantic proximity Read

N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.Semantic proximity Read

Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation.Semantic proximity Read

Slow Outer Hair Cell Contractions Are Essential for Fast Electrical Responses to Intense SoundSemantic proximity Read

A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification.Semantic proximity Read

High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss.Semantic proximity Read