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Article

Direct suppression of host gluconeogenesis by Trypanosoma brucei

2026-01-13

Abstract excerpt

<title>Abstract</title> <p>The cause of hypoglycaemia in African trypanosomiasis remains unresolved. We found that infected mice show normal carbohydrate digestion, intestinal glucose absorption, and tissue glucose uptake, but a profound reduction of host glucose production via gluconeogenesis. Liver transcriptomics uncovered coordinated repression of gluconeogenic pathways alongside inflammatory activation. Infe...

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Literature Corpus work
e793b461-0a3b-5199-a5ed-d884548dc292
DOI
10.21203/rs.3.rs-8369960/v1
Open publication

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Direct suppression of host gluconeogenesis by Trypanosoma bruceiDOI 10.21203/rs.3.rs-8369960/v1
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