Article
Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model.
Oncotarget - 22 Mar 2016
Cabalén María E, Cabral María F, Sanmarco Liliana M, Andrada Marta C, Onofrio Luisina I, Ponce Nicolás E, Aoki María P, Gea Susana, Cano Roxana C
Abstract excerpt
Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been entirely explored. A novel diet-induced obesity model (DIO) was developed in C57BL/6 wild type mice to examine the effect of chronic infection (DIO+I) on metabolic...
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